⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581943 | 0.93 | — | — | |
| SCHEMBL10709212 | 0.85 | FDPS (0.30) | — | |
| SCHEMBL1436543 | 0.82 | TSHR (0.32) | — | |
| SCHEMBL60278 | 0.80 | TSHR (0.35) | — | |
| SCHEMBL498075 | 0.76 | — | — | |
| SCHEMBL8133162 | 0.76 | — | — | |
| SCHEMBL29064055 | 0.76 | TSHR (0.44) | — | |
| SCHEMBL8670374 | 0.76 | TSHR (0.44) | — | |
| SCHEMBL1018876 | 0.76 | TSHR (0.44) | — | |
| SCHEMBL9237381 | 0.73 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2736 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016037223-A1 | DIRHODIUM COMPOUNDS AND METHODS OF USE | GHANEM ASHRAF (AU) | 2016-03-17 | — | — | WO | claimed |
| WO-2006065842-A2 | 5,6,7,8-TETRAHYDROQUINOLINES AND RELATED COMPOUNDS AND USES THEREOF | SYNTA PHARMACEUTICALS CORP. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
| CN-118344325-A | PI3K selective inhibitors | 轩竹生物科技股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118344364-A | Amino-substituted fused heteroaryl compounds, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-113521299-B | Pyrazolopyrimidine derivative or conjugate thereof, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118344365-A | Condensed heteroaryl compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-114845739-B | Pharmaceutical conjugate of eribulin derivative, preparation method and application thereof in medicine | 上海森辉医药有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-113939516-B | Methods and compositions for targeting protein degradation | 珃诺生物医药科技(杭州)有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118339157-A | Hydroindole compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| US-4411753-A | Synthesis of 6-t-alkyl-3-pyridazinones | ELI LILLY AND COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4398044-A | Synthesis of acetyl-T-alkanes | ELI LILLY AND COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4082719-A | ORGANOSILICON AND ALUMINUM COMPOUNDS, CURING CATALYST | DOW CORNING CORPORATION (US) | 1978-04-04 | — | — | US | disclosed |
| US-4026940-A | CLEAVING TERT-BUTYL ESTER WITH STRONG ACID | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-05-31 | — | — | US | disclosed |
| US-4011191-A | HEAT-CURABLE SILICONE ELASTOMER COMPOSITIONS CONTAINING ALKENYLTRIACETOXYSILANES | DOW CORNING CORPORATION (US) | 1977-03-08 | — | — | US | disclosed |
| US-3971747-A | ORGANO-SILICON, EPOXIDE, ALUMINUM CONTAINING CATALYST | DOW CORNING CORPORATION (US) | 1976-07-27 | — | — | US | disclosed |
| US-3954826-A | ANTIBACTERIAL INTERMEDIATES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-05-04 | — | — | US | disclosed |
| US-3941850-A | ANTIOXIDANT | THE QUAKER OATS COMPANY (US) | 1976-03-02 | — | — | US | disclosed |