Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312332 | 1.00 | KCNH2 (0.52) | KCNH2IDO1ALDH1A1MGLLAKR1C3 | |
| SCHEMBL4835427 | 0.94 | IDO1 (0.54) | KCNH2IDO1ALDH1A1MGLLAKR1C3 | |
| SCHEMBL19929796 | 0.86 | KCNH2 (0.66) | KCNH2ALDH1A1MGLLCYP19A1 | |
| P-Nitrophenol SCHEMBL5052436 | 0.84 | NR5A1 (0.51) | KCNH2ALDH1A1MGLLCYP19A1MAPT | |
| Hydrochloric Acid SCHEMBL26626706 | 0.83 | IDO1 (0.57) | KCNH2IDO1AKR1C3MAPT | |
| SCHEMBL9232194 | 0.83 | TSHR (0.54) | KCNH2IDO1ALDH1A1AKR1C3 | |
| Nitrobenzene SCHEMBL22440636 | 0.81 | ALDH1A1 (0.53) | KCNH2ALDH1A1MGLLCYP19A1MAPT | |
| SCHEMBL22121179 | 0.81 | TSHR (0.56) | IDO1ALDH1A1AKR1C3MAPT | |
| SCHEMBL1164057 | 0.81 | TDP1 (0.59) | KCNH2IDO1CYP19A1MAPT | |
| SCHEMBL7087223 | 0.80 | IDO1 (0.61) | IDO1ALDH1A1AKR1C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | KCNH2 2109/4885IDO1 1270/4885ALDH1A1 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.