Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 2/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165721 | 0.96 | HTRA1 (0.36) | HTRA1DDR2HPGDMAPK1BDKRB1 | |
| SCHEMBL765827 | 0.92 | BDKRB1 (0.39) | HTRA1DDR2HPGDMAPK1BDKRB1 | |
| SCHEMBL13165804 | 0.90 | P2RX7 (0.40) | HTRA1DDR2BDKRB1GRM4ALDH1A1 | |
| SCHEMBL13166110 | 0.89 | MAPK14 (0.39) | HPGDBDKRB1CXCR2SCN9A | |
| SCHEMBL13165771 | 0.88 | DDR2 (0.35) | DDR2BDKRB1SCN9A | |
| SCHEMBL13165723 | 0.88 | BDKRB1 (0.35) | DDR2MAPK1BDKRB1SCN9AACACB | |
| SCHEMBL13165722 | 0.87 | SCN9A (0.35) | DDR2SCN9APOLBMMP1MMP13 | |
| SCHEMBL13165774 | 0.87 | DDR2 (0.38) | DDR2BDKRB1GRM4SCN9APOLB | |
| SCHEMBL13165595 | 0.87 | BDKRB1 (0.39) | HPGDMAPK1BDKRB1SCN9APOLB | |
| SCHEMBL13165726 | 0.86 | BDKRB1 (0.41) | DDR2BDKRB1SCN9AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |