Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165721 | 0.95 | HTRA1 (0.36) | BDKRB1HTRA1LMNAGAAALDH1A1 | |
| SCHEMBL13166111 | 0.92 | HTRA1 (0.37) | BDKRB1HTRA1LMNAGAAALDH1A1 | |
| SCHEMBL765174 | 0.90 | DDR2 (0.38) | BDKRB1DDR2KDRMAPK1SCN9A | |
| SCHEMBL10121197 | 0.89 | DDR2 (0.41) | BDKRB1ALDH1A1DDR2KDRMAPK1 | |
| SCHEMBL12238933 | 0.89 | P2RX7 (0.44) | BDKRB1ALDH1A1GRM4KMT2A | |
| SCHEMBL764500 | 0.88 | BDKRB1 (0.43) | BDKRB1HPGDSCN9AMAPK14PSMB11 | |
| SCHEMBL764459 | 0.86 | GRM2 (0.45) | BDKRB1DDR2SCN9AROS1ALK | |
| SCHEMBL765640 | 0.86 | SCN9A (0.38) | BDKRB1ALDH1A1DDR2ACACBSCN9A | |
| SCHEMBL13904206 | 0.86 | BDKRB1 (0.39) | BDKRB1DDR2MAPK1ACACBSCN9A | |
| SCHEMBL764434 | 0.85 | DDR2 (0.38) | BDKRB1DDR2SCN9AROS1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |