Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764459 | 0.96 | GRM2 (0.45) | GRM2DDR2BDKRB1SLC6A9KCNH2 | |
| SCHEMBL13165808 | 0.90 | GRM2 (0.41) | GRM2DDR2BDKRB1TP53MAPT | |
| SCHEMBL13165721 | 0.88 | HTRA1 (0.36) | DDR2BDKRB1CXCR2SCN9AALK | |
| SCHEMBL13166115 | 0.87 | DDR2 (0.36) | GRM2DDR2BDKRB1CXCR2SCN9A | |
| SCHEMBL13165719 | 0.86 | SCN9A (0.36) | BDKRB1SCN9AUBE2MDCUN1D1MAPT | |
| SCHEMBL13166050 | 0.85 | GRM2 (0.40) | GRM2DDR2BDKRB1SLC6A9KCNH2 | |
| SCHEMBL13165672 | 0.85 | BDKRB1 (0.36) | DDR2BDKRB1SCN9AMAPTOPRL1 | |
| SCHEMBL13165713 | 0.85 | MAPK14 (0.40) | BDKRB1CXCR2SCN9AUBE2MDCUN1D1 | |
| SCHEMBL12238934 | 0.85 | GRM2 (0.43) | GRM2DDR2BDKRB1SLC6A9KCNH2 | |
| SCHEMBL13165730 | 0.85 | BDKRB1 (0.43) | BDKRB1KCNH2CXCR2SCN9ARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |