Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 12/20 | 0.52 |
| ▸ | SCNN1A | P37088 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166184 | 0.79 | HTT (0.52) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL13166065 | 0.79 | PLAU (0.49) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL936758 | 0.78 | PLAU (0.49) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL13166342 | 0.78 | PLAU (0.49) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL936760 | 0.78 | PLAU (0.49) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL13166183 | 0.76 | PLAU (0.47) | PLAUSCNN1AKDM4EALDH1A1GLA | |
| SCHEMBL12217782 | 0.75 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CYP1A2CYP2D6NPC1 | |
| SCHEMBL858792 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CYP1A2CYP2D6NPC1 | |
| SCHEMBL13533438 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CYP1A2CYP2D6NPC1 | |
| SCHEMBL858791 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CYP1A2CYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803804-B2 | Substituted pyrazines for use in the treatment of inflammatory or allergic conditions | NOVARTIS AG (CH) | 2010-09-28 | — | — | US | disclosed |
| US-7803804-B2 | Substituted pyrazines for use in the treatment of inflammatory or allergic conditions | NOVARTIS AG (CH) | 2010-09-28 | — | — | US | disclosed |
| US-20080312217-A1 | Organic Compounds | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
| US-20080312217-A1 | Organic Compounds | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312217-A1 | Organic Compounds | TRPA1, TRPV1, CHRM1 | PLAU 2908/4885SCNN1A 13/4885KDM4E 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.