Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17983008 | 0.84 | GLS (0.45) | GLSALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14381658 | 0.78 | CYP1A2 (0.49) | GLSALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17983155 | 0.76 | CYP1A2 (0.48) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17983069 | 0.75 | GLS (0.45) | GLSTDP1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL16655079 | 0.75 | TDP1 (0.47) | TDP1L3MBTL1LMNASMN1; SMN2RAB9A | |
| SCHEMBL14821604 | 0.74 | CYP1A2 (0.49) | GLSALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL4759820 | 0.72 | GLS (0.53) | GLSTDP1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL14821913 | 0.72 | CYP1A2 (0.47) | GLSALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL17983066 | 0.72 | CYP1A2 (0.54) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30434337 | 0.72 | BCHE (0.63) | GLSTDP1L3MBTL1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9689840-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate | BIO-RAD LABORATORIES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9689840-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate | BIO-RAD LABORATORIES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | BIO RAD LABORATORIES INC (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | BIO RAD LABORATORIES INC (US) | 2016-08-04 | — | — | US | disclosed |
| US-9274103-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9274103-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2547666-B1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO RAD LABORATORIES (US) | 2015-11-04 | — | — | EP | disclosed |
| US-20140057293-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20140057293-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8536162-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536162-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| WO-2011115802-A1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | CYP24A1, PTMS, CYP27B1 | GLS 1217/4885TDP1 1817/4885L3MBTL1 3460/4885 |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | CYP24A1, PTMS, CYP27B1 | GLS 1163/4885TDP1 1766/4885L3MBTL1 3405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.