Sugi Predict

Sugi Predict / Targets / CYP27B1

CYP27B1

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial · O15528 · CYP27B1 on Sugi Atlas →

4,553 patent compounds predicted against CYP27B1, 3,715 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1503385 SCHEMBL1503385 1.00 2/20
SCHEMBL1503388 SCHEMBL1503388 1.00 2/20
SCHEMBL7126449 SCHEMBL7126449 0.94 2/20
SCHEMBL7070181 SCHEMBL7070181 0.77 2/20
SCHEMBL7068187 SCHEMBL7068187 0.70 2/20
SCHEMBL7066367 SCHEMBL7066367 0.69 2/20
SCHEMBL7068036 SCHEMBL7068036 0.64 2/20
SCHEMBL7071390 SCHEMBL7071390 0.64 2/20
SCHEMBL7072584 SCHEMBL7072584 0.64 2/20
SCHEMBL2163893 SCHEMBL2163893 0.62 2/20
SCHEMBL2163897 SCHEMBL2163897 0.62 2/20
SCHEMBL7130248 SCHEMBL7130248 0.59 2/20
SCHEMBL7126496 SCHEMBL7126496 0.55 2/20
SCHEMBL6983161 SCHEMBL6983161 0.53 2/20
SCHEMBL5260012 SCHEMBL5260012 0.52 2/20
SCHEMBL7126453 SCHEMBL7126453 0.52 2/20
SCHEMBL7129271 SCHEMBL7129271 0.52 2/20
SCHEMBL410598 SCHEMBL410598 0.51 2/20
SCHEMBL6318924 SCHEMBL6318924 0.51 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL4881143) 0.50 2/20

Clinical trials — most relevant to CYP27B1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients PHASE4COMPLETED
Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D PHASE4COMPLETED
Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism PHASE4COMPLETED
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy PHASE3COMPLETED
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea PHASE3COMPLETED
Cholecalciferol on Depressive Symptoms in Type 2 Diabetes Mellitus Patients PHASE2UNKNOWN
Vitamin D Supplementation in Cirrhotic Patients PHASE2COMPLETED
Vitamin D Supplementation in HIV-infected Youth PHASE2COMPLETED
Effects of Vitamin D Supplementation on Muscle Protein Synthesis PHASE2COMPLETED
The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients PHASE2UNKNOWN
The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH PHASE1UNKNOWN
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults EARLY_PHASE1COMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer nanCOMPLETED
Hypercalcemia After Paraffin Oil Injection nanRECRUITING
Vitamin D and the Free Hormone Hypothesis nanCOMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Non-inferiority RCT on Fish Waste-Derived vs. Synthetic Vitamin D Supplementation in Healthy Adults With Suboptimal Vitamin D Levels nanNOT_YET_RECRUITING
Vitamin D Analog in Vitamin D 24-hydroxylase Deficiency nanRECRUITING
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients nanCOMPLETED
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism nanCOMPLETED
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease nanCOMPLETED
Predictors of Outcome of Pediatric Renal Transplantation nanNOT_YET_RECRUITING
Prevalence of Serum-Vitamin D Abnormalities, Periodontitis and Anaemia in Patients With Melasma nanCOMPLETED
Serum and Semen Vitamin D Level With Semen Parameters nanUNKNOWN
Vitamin D Levels in SARS-CoV-2: Do Current Adequacy Thresholds Reflect Clinical Risk? Insights From a Large Turkish Cohort nanCOMPLETED
Ultraviolet Light And Vitamin D In Subjects With Fat Malabsorption Or After Gastric Bypass Surgery nanCOMPLETED
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density nanRECRUITING
Pharmacokinetics of Calcifediol and Cholecalciferol nanCOMPLETED
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CYP27B1 binder may also engage these)

ProteinNameSimilarity
O35132 — 0.998 O35132 →
O35084 — 0.996 O35084 →
P17177 — 0.984 P17177 →
B2RXA7 — 0.980 B2RXA7 →
P97720 — 0.978 P97720 →
Q4G0S4 — 0.976 Q4G0S4 →
Q2LCM1 — 0.976 Q2LCM1 →
P15540 — 0.975 P15540 →
Q8WNW0 — 0.975 Q8WNW0 →
Q9DBG1 — 0.974 Q9DBG1 →
CYP27A1 Sterol 26-hydroxylase, mitochondrial 0.972 landscape →
P17178 — 0.972 P17178 →
Q6V0L0 — 0.972 Q6V0L0 →
Q2LA59 — 0.971 Q2LA59 →
Q64408 — 0.971 Q64408 →
Q2LA60 — 0.971 Q2LA60 →
CYP21A2 Steroid 21-hydroxylase 0.971 landscape →
P00191 — 0.971 P00191 →
Q28827 — 0.971 Q28827 →
P12394 — 0.969 P12394 →
A0A087X1C5 — 0.968 A0A087X1C5 →
CYP2D6 Cytochrome P450 2D6 0.968 landscape →
P00189 — 0.967 P00189 →
Q29488 — 0.967 Q29488 →
O46515 — 0.966 O46515 →
CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase 0.966 landscape →
O18992 — 0.966 O18992 →
Q2XNC8 — 0.965 Q2XNC8 →
P15393 — 0.965 P15393 →
P70085 — 0.965 P70085 →