⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16951940 | 0.79 | L3MBTL1 (0.50) | — | |
| SCHEMBL10287939 | 0.79 | ALDH1A1 (0.52) | — | |
| SCHEMBL28861335 | 0.77 | ALDH1A1 (0.86) | — | |
| Bromide SCHEMBL8039510 | 0.77 | ALDH1A1 (0.50) | — | |
| SCHEMBL1058814 | 0.77 | ALDH1A1 (0.62) | — | |
| SCHEMBL3301954 | 0.77 | ALDH1A1 (0.62) | — | |
| SCHEMBL9586694 | 0.77 | ALDH1A1 (0.62) | — | |
| SCHEMBL16953070 | 0.75 | ALDH1A1 (0.38) | — | |
| SCHEMBL16955594 | 0.75 | ALDH1A1 (0.46) | — | |
| SCHEMBL16960255 | 0.75 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999740-B2 | Fused pyrazine derivatives as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2024-06-04 | — | — | US | claimed |
| US-20220135570-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-05-05 | — | — | US | claimed |
| EP-3818063-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | Incyte Corporation (US) | 2021-05-12 | — | — | EP | claimed |
| US-20200031835-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2020-01-30 | — | — | US | claimed |
| CN-102482731-B | Method for recovering metals from aqueous solutions | CYTEC TECH CORP | 2015-06-10 | — | — | CN | claimed |
| US-8791102-B2 | Acetanilide sphingosine-1-phosphate receptor antagonists | EXELIXIS, INC. (US) | 2014-07-29 | — | — | US | claimed |
| US-20110288076-A1 | Sphingosine-1-Phosphate Receptor Antagonists | EXELIXIS, INC. (US) | 2011-11-24 | — | — | US | claimed |
| CN-102256944-A | Sphingosine-1-phosphate receptor antagonists | EXELIXIS INC | 2011-11-23 | — | — | CN | claimed |
| CN-101903317-A | Improved process for the preparation of 2- (substituted phenyl) -2 hydroxy-ethylcarbamates | JANSSEN PHARMACEUTICA NV | 2010-12-01 | — | — | CN | claimed |
| US-11999740-B2 | Fused pyrazine derivatives as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2024-06-04 | — | — | US | disclosed |
| US-20220135570-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-05-05 | — | — | US | disclosed |
| US-11161850-B2 | Fused pyrazine derivatives as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2021-11-02 | — | — | US | disclosed |
| EP-3818063-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | Incyte Corporation (US) | 2021-05-12 | — | — | EP | disclosed |
| US-20200031835-A1 | FUSED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2020-01-30 | — | — | US | disclosed |
| US-4610861-A | COBALT, PHOSPHINIC ACID AS EXTRACTANT | INCO LIMITED (CA) | 1986-09-09 | — | — | US | disclosed |
| US-4382016-A | ORGANIC PHOSPHINIC ACID | AMERICAN CYANAMID COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4353883-A | Selective extraction of cobalt(II) from aqueous solutions with phosphinic acid extractants | AMERICAN CYANAMID COMPANY (US) | 1982-10-12 | — | — | US | disclosed |
| US-4348367-A | Selective removal of cobalt(II) from aqueous solutions with phosphinic extractants | AMERICAN CYANAMID COMPANY (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0046940-A2 | Extraction process for the selective removal of cobalt (II) from aqueous solutions | CYANAMID CANADA INC. (CA) | 1982-03-10 | — | — | EP | disclosed |
| EP-0046933-A2 | Extraction process for the selective removal of cobalt (II) from aqueous solutions | CYANAMID CANADA INC. (CA) | 1982-03-10 | — | — | EP | disclosed |