Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.36 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19679203 | 0.82 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL19667421 | 0.81 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL10186279 | 0.81 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL10186280 | 0.81 | NAE1 (0.41) | PRMT5WDR77ADCY5 | |
| SCHEMBL19684699 | 0.80 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL19667418 | 0.75 | ADCY5 (0.39) | PRMT5WDR77ADCY5 | |
| SCHEMBL19667419 | 0.74 | ADCY5 (0.40) | PRMT5WDR77ADCY5 | |
| SCHEMBL20911154 | 0.74 | PRMT5 (0.38) | PRMT5WDR77ADCY5 | |
| SCHEMBL30207974 | 0.73 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL19667368 | 0.73 | PRMT5 (0.39) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136024-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. | 2017-05-18 | — | — | US | disclosed |
| US-20130289037-A1 | INHIBITORS OF E1 ACTIVTING ENZYMES | MILLENNIUM PHARM INC (US) | 2013-10-31 | — | — | US | disclosed |
| US-20130165457-A9 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120258927-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENIUM PHARMACEUTICALS, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120258977-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258977-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885ADCY5 2762/4885 |
| US-20120258927-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885ADCY5 2762/4885 |
| US-20170136024-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885ADCY5 2762/4885 |
| US-20130165457-A9 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885ADCY5 2762/4885 |
| US-20130289037-A1 | INHIBITORS OF E1 ACTIVTING ENZYMES | RNASE1, ECE1, CES1 | PRMT5 822/4885WDR77 2267/4885ADCY5 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.