SCHEMBL1317082

SCHEMBL1317082

COC(=O)c1ccc(Br)cc1NC(=O)c1cc(C2CCNCC2)ccc1OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 4/20 0.53
LRRK2 Q5S007 12/20 0.49
ABCG2 Q9UNQ0 2/20 0.42
BRD4 O60885 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317015 0.90 PRMT5 (0.55) PRMT5LRRK2BRD4
SCHEMBL1318450 0.89 LRRK2 (0.62) PRMT5LRRK2ABCG2
SCHEMBL12121423 0.86 KDM4E (0.40) PRMT5LRRK2ABCG2L3MBTL1
SCHEMBL27828450 0.86 LRRK2 (0.48) PRMT5LRRK2BRD4TDP1L3MBTL1
SCHEMBL1317419 0.84 LRRK2 (0.49) LRRK2
SCHEMBL12117497 0.82 ABCG2 (0.44) ABCG2
SCHEMBL27847125 0.81 LRRK2 (0.51) PRMT5LRRK2BRD4TDP1L3MBTL1
SCHEMBL27989362 0.80 LRRK2 (0.49) PRMT5LRRK2BRD4
SCHEMBL27828451 0.80 LRRK2 (0.49) PRMT5LRRK2BRD4
SCHEMBL12121553 0.79 PRMT5 (0.43) PRMT5LRRK2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 PRMT5 1535/4885LRRK2 1813/4885ABCG2 4744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.