Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13192084 | 0.89 | HTT (0.50) | HTTCCNE2CCNE1CDK2TLR7 | |
| SCHEMBL13171146 | 0.82 | HTT (0.53) | HTTCTNNB1TCF7L2GRK6GBA1 | |
| SCHEMBL13171145 | 0.81 | HTT (0.52) | HTTCTNNB1TCF7L2GRK6GBA1 | |
| SCHEMBL9921328 | 0.81 | KRAS (0.50) | HTTCTNNB1TCF7L2GRK6ALDH1A1 | |
| SCHEMBL9921353 | 0.78 | HTT (0.77) | HTTKMT2ALMNA | |
| SCHEMBL9921339 | 0.76 | HTT (0.51) | HTTCTNNB1TCF7L2GRK6LMNA | |
| SCHEMBL9921340 | 0.75 | HTT (0.50) | HTTCTNNB1TCF7L2GRK6LMNA | |
| SCHEMBL9921377 | 0.71 | HTT (0.74) | HTTLMNA | |
| SCHEMBL13171085 | 0.71 | HTT (0.67) | HTTALDH1A1LMNA | |
| SCHEMBL31045237 | 0.70 | TLR7 (0.39) | HTTCCNE2CCNE1CDK2TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | HTT 4078/4885CCNE2 3624/4885CCNE1 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.