SQSTM1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5311299	0.69	7/20
SCHEMBL7956056	0.47	4/20
SCHEMBL6561666	0.70	3/20
SCHEMBL6953396	0.55	3/20
SCHEMBL6953401	0.55	3/20
SCHEMBL1377079	0.67	2/20
SCHEMBL4954492	0.63	2/20
SCHEMBL1775785	0.61	2/20
Hydrochloric Acid (SCHEMBL1773873)	0.60	2/20
SCHEMBL1775654	0.59	2/20
SCHEMBL4954785	0.58	2/20
Hydrochloric Acid (SCHEMBL1776067)	0.58	2/20
SCHEMBL2981038	0.53	2/20
SCHEMBL3559360	0.53	2/20
SCHEMBL3268814	0.53	2/20
SCHEMBL7832927	0.52	2/20
SCHEMBL3551606	0.52	2/20
SCHEMBL1465268	0.51	2/20
SCHEMBL3551774	0.51	2/20
SCHEMBL7321125	0.51	2/20

Clinical trials — most relevant to SQSTM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients	PHASE3	COMPLETED
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients	PHASE2	UNKNOWN
Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes	PHASE2	RECRUITING
Colchicine for Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Hydroxychloroquine, Capecitabine, Oxaliplatin, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer	PHASE2	COMPLETED
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction	EARLY_PHASE1	RECRUITING
Time Course for Fasting-induced Autophagy in Humans	nan	WITHDRAWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
The Role of Fibroblast Activation in Uterine Fibroid	nan	COMPLETED
Autophagy Markers in Endometrial Polyps	nan	COMPLETED
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm	nan	COMPLETED
2-A-Day Study: Twice a Day Meals Study.	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS	nan	UNKNOWN
Autophagy/Apoptosis Balance in Placental Vascular Pathologies	nan	RECRUITING
Immunohistochemical Assessment of Programmed Death ligand1 and LC3B in GBM	nan	UNKNOWN
Autophagy and Pathological Aging	nan	COMPLETED
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Strong Evidence: Digitally Delivered Exercise in Older Adults	nan	ACTIVE_NOT_RECRUITING
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy	nan	COMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
mTORC1 and Autophagy in Human Brown Adipocytes	nan	COMPLETED
Muscle Insulin Resistance in Aging (Mirage)	nan	ACTIVE_NOT_RECRUITING
Evaluation of Serum Autophagic Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Individuals	nan	ENROLLING_BY_INVITATION
Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administration of a Supplement Rich in Oleuropein From the Olive Leaf	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SQSTM1 binder may also engage these)

Protein	Name	Similarity
Q5RBA5	—	1.000	Q5RBA5 →
O08623	—	1.000	O08623 →
Q64337	—	1.000	Q64337 →
Q08E13	—	0.992	Q08E13 →
Q9BQI7	—	0.990	Q9BQI7 →
Q9D2Q3	—	0.990	Q9D2Q3 →
Q6P1I6	—	0.989	Q6P1I6 →
Q6ZPS6	—	0.989	Q6ZPS6 →
Q76LL6	—	0.989	Q76LL6 →
Q1LYM3	—	0.989	Q1LYM3 →
MAP3K9	Mitogen-activated protein kinase kinase kinase 9	0.989	landscape →
Q6PCQ0	—	0.989	Q6PCQ0 →
Q1L8G6	—	0.989	Q1L8G6 →
RNF10	E3 ubiquitin-protein ligase RNF10	0.988	landscape →
Q6A037	—	0.988	Q6A037 →
Q8K3A9	—	0.988	Q8K3A9 →
O95343	—	0.988	O95343 →
Q9BQK8	—	0.988	Q9BQK8 →
Q640U0	—	0.988	Q640U0 →
Q08BW0	—	0.988	Q08BW0 →
Q5T124	—	0.988	Q5T124 →
Q1LUT1	—	0.988	Q1LUT1 →
O70405	—	0.988	O70405 →
Q3U2S4	—	0.988	Q3U2S4 →
Q9CYA6	—	0.988	Q9CYA6 →
Q8C0J6	—	0.988	Q8C0J6 →
P12813	—	0.987	P12813 →
Q5XI59	—	0.987	Q5XI59 →
Q640H3	—	0.987	Q640H3 →
Q76N89	—	0.987	Q76N89 →