Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1668350 | 0.84 | KMT2A (0.56) | PKMHTTNPC1RAB9AKMT2A | |
| SCHEMBL6880415 | 0.77 | PKM (0.53) | PKMHTTNPC1RAB9AKMT2A | |
| SCHEMBL1230603 | 0.74 | KMT2A (0.56) | PKMHTTKMT2AMEN1MAPT | |
| SCHEMBL13173290 | 0.73 | PKM (0.57) | PKMHTTNPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL2290641 | 0.73 | KMT2A (0.56) | PKMHTTKMT2AMEN1MAPT | |
| SCHEMBL18353117 | 0.72 | SMN1; SMN2 (0.61) | PKMHTTNPC1MAPTTSHR | |
| SCHEMBL2379008 | 0.72 | TSHR (0.66) | PKMHTTKMT2AMEN1MAPT | |
| SCHEMBL8592338 | 0.72 | HTT (0.49) | PKMHTTNPC1RAB9AKMT2A | |
| SCHEMBL6207754 | 0.72 | KMT2A (0.71) | PKMNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL13777923 | 0.71 | POLB (0.69) | PKMHTTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228370-A1 | N-{1-Ý3-(2-ETHOXY-5-(4-ETHYLPIPERAZINYL)BENZENESULFONYL)-4,5-DIHYDRO-5-OXO-1,2,4-TRIAZIN-6-YL¨ETHYL}BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2010-09-15 | — | — | EP | disclosed |