Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.67 |
| ▸ | TRPV4 | Q9HBA0 | 9/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16366780 | 0.90 | TRPA1 (0.65) | TRPA1TRPV4 | |
| SCHEMBL13834769 | 0.87 | TRPA1 (0.74) | TRPA1TRPV4 | |
| SCHEMBL13175032 | 0.85 | TRPA1 (0.61) | TRPA1TRPV4 | |
| SCHEMBL13175038 | 0.85 | TRPA1 (0.77) | TRPA1TRPV4 | |
| SCHEMBL13075868 | 0.83 | TRPA1 (0.63) | TRPA1TRPV4 | |
| SCHEMBL13075960 | 0.83 | TRPA1 (0.69) | TRPA1TRPV4 | |
| SCHEMBL13076890 | 0.82 | TRPA1 (0.62) | TRPA1TRPV4 | |
| SCHEMBL474685 | 0.81 | TRPA1 (0.83) | TRPA1TRPV4 | |
| SCHEMBL10275196 | 0.80 | TRPA1 (1.00) | TRPA1TRPV4 | |
| SCHEMBL15241202 | 0.79 | TRPA1 (0.68) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109334-A2 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |