Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 15/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13175031 | 0.86 | TRPA1 (0.59) | TRPA1MAPTSMN1; SMN2RORCTRPV4 | |
| SCHEMBL13174923 | 0.85 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13834483 | 0.85 | TRPA1 (0.82) | TRPA1MAPTSMN1; SMN2TRPV4 | |
| SCHEMBL15241216 | 0.81 | TRPA1 (0.60) | TRPA1MAPTSMN1; SMN2RORCABL1 | |
| SCHEMBL13075853 | 0.80 | TRPA1 (0.54) | TRPA1MAPTSMN1; SMN2RORCTRPV4 | |
| SCHEMBL13834482 | 0.76 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13834518 | 0.75 | TRPA1 (0.75) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13834747 | 0.75 | TRPA1 (0.63) | TRPA1MAPTSMN1; SMN2TRPV4 | |
| SCHEMBL474692 | 0.75 | TRPA1 (0.65) | TRPA1MAPTSMN1; SMN2TRPV4TRPV3 | |
| SCHEMBL16366780 | 0.74 | TRPA1 (0.65) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109334-A2 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |