Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 19/20 | 0.74 |
| ▸ | THRB | P10828 | 19/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920565 | 0.85 | THRA (1.00) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL23245074 | 0.79 | THRA (0.88) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL31405760 | 0.77 | THRA (0.56) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL22632647 | 0.74 | THRA (0.91) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL22632431 | 0.74 | THRA (0.53) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL31405709 | 0.74 | THRA (0.53) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL22632519 | 0.73 | THRA (0.52) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL698134 | 0.73 | THRB (0.51) | THRATHRBCYP2C9CYP2C8 | |
| SCHEMBL2927758 | 0.72 | THRA (0.70) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL2927895 | 0.72 | THRA (1.00) | THRATHRBCYP2C9CYP2C8UGT1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919878-B1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-08 | — | — | EP | disclosed |