Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.71 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.71 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.65 |
| ▸ | RXRA | P19793 | 1/20 | 0.60 |
| ▸ | RXRB | P28702 | 1/20 | 0.60 |
| ▸ | RXRG | P48443 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.56 |
| ▸ | STS | P08842 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29686111 | 1.00 | PTPN2 (0.71) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL29971632 | 1.00 | PTPN2 (0.71) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL3557554 | 0.94 | PTPN2 (0.81) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL5870918 | 0.93 | ABL1 (0.62) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL3715390 | 0.93 | ABL1 (0.62) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL28768913 | 0.92 | PTPN2 (0.79) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL12771465 | 0.90 | PTPN1 (0.88) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL5870903 | 0.90 | PTPN2 (0.62) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL15686544 | 0.89 | PTPN2 (0.73) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL12771496 | 0.88 | PTPN2 (0.72) | PTPN2PTPN1PTPN6ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PTPN2 674/4885PTPN1 524/4885PTPN6 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.