Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | KHK | P50053 | 13/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318715 | 0.93 | AURKA (0.43) | AURKAPDPK1AURKBKHKADORA1 | |
| SCHEMBL1318659 | 0.90 | AURKA (0.48) | AURKAPDPK1AURKB | |
| SCHEMBL1317905 | 0.88 | AURKA (0.45) | AURKAPDPK1AURKBKHK | |
| SCHEMBL1318215 | 0.87 | KHK (0.35) | AURKAPDPK1AURKBKHK | |
| SCHEMBL16966439 | 0.82 | AURKA (0.38) | AURKAPDPK1AURKBKHKADORA1 | |
| SCHEMBL1318421 | 0.82 | AURKA (0.41) | AURKAPDPK1AURKBKHKADORA1 | |
| SCHEMBL1318597 | 0.81 | CHRM2 (0.34) | AURKAPDPK1AURKBKHKADORA1 | |
| SCHEMBL12119836 | 0.80 | AURKA (0.51) | AURKAPDPK1AURKB | |
| SCHEMBL1318713 | 0.79 | AURKA (0.43) | AURKAPDPK1AURKB | |
| SCHEMBL1318843 | 0.78 | AURKA (0.48) | AURKAPDPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | AURKA 298/4885PDPK1 12/4885AURKB 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.