Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178263 | 0.90 | MAOB (0.53) | NPC1RAB9ASMN1; SMN2KDRMAOB | |
| SCHEMBL13841886 | 0.88 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL13178420 | 0.88 | PRKAB2 (0.45) | NPC1RAB9AKDRMAOB | |
| SCHEMBL5616970 | 0.87 | KDR (0.48) | KDRMAOBGRM5 | |
| SCHEMBL13178370 | 0.87 | KDR (0.65) | NPC1RAB9AKDRMAOBFLT3 | |
| SCHEMBL13178371 | 0.87 | KDR (0.55) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL13841920 | 0.86 | KDR (0.43) | RAB9ASMN1; SMN2MAPTL3MBTL1KDR | |
| SCHEMBL13842178 | 0.85 | KDR (0.43) | KDRMAOB | |
| SCHEMBL13842172 | 0.84 | KDR (0.42) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL13842181 | 0.84 | KDR (0.43) | KDRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812440-B1 | PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-09-22 | — | — | EP | disclosed |
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |
| US-7528138-B2 | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-05 | — | — | US | disclosed |