Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 16/20 | 0.66 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.66 |
| ▸ | AURKA | O14965 | 10/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.62 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317951 | 0.91 | PDPK1 (0.65) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1317038 | 0.86 | PDPK1 (0.73) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1318299 | 0.80 | PDPK1 (1.00) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1319045 | 0.80 | PDPK1 (0.67) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1319607 | 0.80 | PDPK1 (0.64) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1318024 | 0.79 | PDPK1 (0.69) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL24137797 | 0.78 | JAK2 (0.51) | PDPK1TGFBR1AURKAAURKBJAK3 | |
| SCHEMBL13354782 | 0.78 | HRH4 (0.49) | HRH4HRH3 | |
| SCHEMBL1321037 | 0.78 | PDPK1 (0.82) | PDPK1TGFBR1AURKAAURKBROCK1 | |
| SCHEMBL1318884 | 0.77 | PDPK1 (0.63) | PDPK1TGFBR1AURKAAURKBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | claimed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | claimed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | claimed |
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PDPK1 12/4885TGFBR1 1687/4885AURKA 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.