Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 17/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 16/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.77 |
| ▸ | AURKA | O14965 | 11/20 | 0.65 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316853 | 0.87 | PDPK1 (1.00) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1319103 | 0.87 | PDPK1 (0.86) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL12118796 | 0.84 | PDPK1 (0.76) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318451 | 0.79 | PDPK1 (1.00) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL2477825 | 0.78 | PDPK1 (0.67) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1318996 | 0.77 | PDPK1 (0.80) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1320752 | 0.77 | PDPK1 (0.68) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL1317753 | 0.76 | PDPK1 (0.67) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL16966478 | 0.74 | PDPK1 (0.84) | PDPK1AURKBROCK1AURKATGFBR1 | |
| SCHEMBL16966479 | 0.74 | PDPK1 (0.84) | PDPK1AURKBROCK1AURKATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PDPK1 12/4885AURKB 262/4885ROCK1 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.