Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17041588 | 0.84 | TRPA1 (0.44) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL23548856 | 0.82 | CA1 (0.40) | TRPA1AAK1CA1CA2CA7 | |
| SCHEMBL23199606 | 0.82 | CA1 (0.40) | TRPA1AAK1CA1CA2CA7 | |
| SCHEMBL15092375 | 0.82 | AAK1 (0.57) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL21456250 | 0.82 | AAK1 (0.57) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL30578931 | 0.82 | AAK1 (0.57) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL9947819 | 0.82 | AAK1 (0.57) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL29373654 | 0.82 | AAK1 (0.57) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL16046901 | 0.81 | TRPA1 (0.49) | TRPA1AAK1CTSSCTSKKMT2A | |
| SCHEMBL18040191 | 0.81 | AAK1 (0.42) | TRPA1AAK1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790754-B2 | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists | MERCK SHARP & DOHME CORP. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1706372-B1 | ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS | MERCK SHARP & DOHME (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20080318976-A1 | Alpha-Hydroxy Amides as Bradykinin Antagonists or Inverse Agonists | MERCK SHARP & DOHME CORP. | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318976-A1 | Alpha-Hydroxy Amides as Bradykinin Antagonists or Inverse Agonists | BDKRB1, BDKRB2, HCAR2 | TRPA1 128/4885AAK1 1795/4885CA1 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.