Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.52 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13183137 | 0.86 | JAK2 (0.44) | JAK2MKNK1CHEK1GSK3BCDK2 | |
| SCHEMBL13183135 | 0.85 | DYRK1A (0.47) | JAK2MKNK1CHEK1TTKGSK3B | |
| SCHEMBL5511824 | 0.81 | CHEK1 (0.78) | JAK2MKNK1CHEK1CDK2CDK1 | |
| SCHEMBL5511827 | 0.81 | CHEK1 (0.78) | JAK2MKNK1CHEK1CDK2CDK1 | |
| SCHEMBL11913101 | 0.80 | JAK2 (0.46) | JAK2MKNK1TTKGSK3ACDK2 | |
| SCHEMBL25419245 | 0.78 | TRPA1 (0.52) | JAK2CLK4HPGDKDM4EALDH1A1 | |
| SCHEMBL31472533 | 0.78 | TRPA1 (0.52) | JAK2CLK4HPGDKDM4EALDH1A1 | |
| SCHEMBL17306449 | 0.78 | MKNK1 (0.87) | JAK2MKNK1TTKGSK3BGSK3A | |
| SCHEMBL13548700 | 0.77 | KDR (0.56) | CHEK1TTKCDK4CCND1CCND3 | |
| SCHEMBL26393980 | 0.77 | GSK3B (0.57) | JAK2MKNK1CHEK1TTKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790722-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090088437-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088437-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA1 | JAK2 1182/4885MKNK1 2098/4885CHEK1 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.