Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.87 |
| ▸ | JAK2 | O60674 | 4/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.69 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.69 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
| ▸ | FER | P16591 | 1/20 | 0.69 |
| ▸ | MARK3 | P27448 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.69 |
| ▸ | CLK2 | P49760 | 1/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.69 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508162 | 0.93 | MKNK1 (1.00) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL17306477 | 0.93 | MKNK1 (0.76) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL8437976 | 0.92 | MKNK1 (0.74) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL5514698 | 0.87 | MKNK1 (0.72) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL1513016 | 0.85 | FGFR1 (0.71) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL17178615 | 0.84 | ALDH1A1 (0.92) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL5514710 | 0.83 | MKNK1 (0.63) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL12907246 | 0.83 | JAK2 (1.00) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL3359889 | 0.83 | JAK2 (1.00) | MKNK1JAK2MAP4K4CDK2CLK4 | |
| SCHEMBL5516414 | 0.83 | MKNK1 (0.62) | MKNK1JAK2MAP4K4CDK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015182769-A1 | QUINAZOLINE AND BENZOQUINAZOLINE COMPOUNDS AND PRODUCTION AND USE OF SAME | 東ソー株式会社 | 2015-12-03 | — | — | WO | disclosed |