Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 18/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380645 | 0.77 | PDE3A (0.54) | PDE3APDE4BPDE3BMEN1ALDH1A1 | |
| SCHEMBL2840727 | 0.73 | PDE3A (0.40) | PDE3APDE4BPDE3B | |
| SCHEMBL6563643 | 0.72 | PDE3A (0.42) | PDE3APDE4BPDE3B | |
| SCHEMBL11101816 | 0.69 | NPC1 (0.45) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2844398 | 0.67 | PDE3A (0.45) | PDE3APDE4BPDE3B | |
| SCHEMBL16150403 | 0.67 | PDE3A (0.55) | PDE3APDE4BPDE3B | |
| SCHEMBL2847376 | 0.67 | PDE3A (0.55) | PDE3APDE4BPDE3B | |
| SCHEMBL16150009 | 0.67 | PDE3A (0.55) | PDE3APDE4BPDE3BMEN1ALDH1A1 | |
| SCHEMBL2847233 | 0.66 | PDE3A (0.57) | PDE3APDE4BPDE3B | |
| SCHEMBL5183107 | 0.66 | PDE3A (0.44) | PDE3APDE4BPDE3BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010110400-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-09-30 | — | — | WO | disclosed |