Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 13/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16150403 | 0.81 | PDE3A (0.55) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL16150009 | 0.81 | PDE3A (0.55) | PDE3APDE3BPDE4BALDH1A1SMN1; SMN2 | |
| SCHEMBL2847376 | 0.81 | PDE3A (0.55) | PDE3APDE3BPDE4BMMP2MMP9 | |
| SCHEMBL2847471 | 0.80 | PDE3A (0.44) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL5183107 | 0.80 | PDE3A (0.44) | PDE3APDE3BPDE4BAXLPDE4A | |
| SCHEMBL2844753 | 0.79 | PDE3A (0.52) | PDE3APDE3BPDE4BGAA | |
| SCHEMBL9669163 | 0.78 | CYP19A1 (0.47) | PDE3APDE3BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16150897 | 0.78 | PDE3B (0.51) | PDE3APDE3BGAA | |
| SCHEMBL2844964 | 0.77 | PGR (0.53) | PDE3APDE3BPDE4BALDH1A1GAA | |
| SCHEMBL13183458 | 0.77 | PDE3A (0.45) | PDE3APDE3BPDE4BALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4661496-A | Cardiotonic and antihypertensive 2,4-dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| US-4550119-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1985-10-29 | — | — | US | disclosed |
| US-4526982-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY, A CORP. OF DEL. | 1985-07-02 | — | — | US | disclosed |
| EP-0126651-A2 | 2,4-Dihydro-5-((substituted)phenyl)-4,4-disubstituted-3H-pyrazol-3-ones, 2,4-dihydro-5-((substituted)phenyl)-4, 4-disubstituted-3H-pyrazol-3-thiones, and a process for producing the same | WARNER-LAMBERT COMPANY (US) | 1984-11-28 | — | — | EP | disclosed |