Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | FYN | P06241 | 6/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13160647 | 0.82 | FYN (0.42) | SRCFYNBTKEGFRLYN | |
| SCHEMBL14453773 | 0.81 | F2 (0.41) | SRC | |
| SCHEMBL14453778 | 0.81 | F2 (0.41) | SRC | |
| SCHEMBL14453781 | 0.81 | F2 (0.41) | SRC | |
| SCHEMBL14471400 | 0.79 | SRC (0.56) | SRCFYNBTKRIPK1LYN | |
| SCHEMBL13160649 | 0.77 | SRC (0.45) | SRCFYNBTKFGFR1FGFR2 | |
| SCHEMBL14453784 | 0.75 | NPY1R (0.45) | — | |
| SCHEMBL14471392 | 0.71 | SRC (0.51) | SRCFYNBTKFGFR1FGFR2 | |
| SCHEMBL13183399 | 0.69 | CASP1 (0.51) | — | |
| SCHEMBL14453776 | 0.68 | F2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799753-B2 | Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents | Board of Governers for Higher Education (US) | 2010-09-21 | — | — | US | disclosed |