Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | RAD51 | Q06609 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.77 |
| ▸ | PKM | P14618 | 4/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | RAD1 | O60671 | 1/20 | 0.68 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13186473 | 0.88 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL17208334 | 0.84 | L3MBTL1 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL13186558 | 0.82 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL13186471 | 0.81 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL13186620 | 0.81 | MAPT (0.73) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL15758553 | 0.79 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL15758820 | 0.79 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL15758239 | 0.78 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL15758766 | 0.78 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL15758684 | 0.78 | RAD51 (1.00) | MAPTRAD51SMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198914-B2 | Methods and compositions for modulating RAD51 and homologous recombination | THE UNIVERSITY OF CHICAGO (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | THE UNIVERSITY OF CHICAGO (US) | 2014-05-22 | — | — | US | disclosed |
| US-20100248371-A1 | METHODS AND COMPOSITIONS FOR MODULATING RAD51 AND HOMOLOGOUS RECOMBINATION | UNIVERSITY OF CHICAGO (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | RAD51, MRE11, RAD50 | MAPT 3907/4885RAD51 1/4885SMN1; SMN2 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.