Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 3/20 | 0.52 |
| ▸ | MOK | Q9UQ07 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713979 | 0.94 | GRM2 (0.51) | GRM2ACP1MOKJAK2JAK1 | |
| SCHEMBL13188454 | 0.87 | GRM2 (0.56) | GRM2ACP1MOKKDM4ELMNA | |
| SCHEMBL13188224 | 0.78 | GRM2 (0.55) | GRM2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14393596 | 0.77 | SMN1; SMN2 (0.47) | ACP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13187729 | 0.77 | SMN1; SMN2 (0.51) | KDM4ELMNAALDH1A1HDAC1MAPK1 | |
| SCHEMBL18520757 | 0.77 | PDE2A (0.44) | GRM2PDE10APIK3CDMAPK1SMN1; SMN2 | |
| SCHEMBL18895622 | 0.73 | GRM2 (0.82) | GRM2 | |
| SCHEMBL985861 | 0.73 | P2RY12 (0.57) | MOKKDM4ELMNAALDH1A1MAPK1 | |
| SCHEMBL13188229 | 0.73 | DHODH (0.53) | GRM2KDM4EALDH1A1 | |
| SCHEMBL13188651 | 0.72 | SMN1; SMN2 (0.53) | GRM2LMNAALDH1A1HDAC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |