Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MOK | Q9UQ07 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188262 | 0.87 | GRM2 (0.55) | GRM2HDAC1MOKALDH1A1PIK3CD | |
| SCHEMBL3713979 | 0.81 | GRM2 (0.51) | GRM2MOKALDH1A1KDM4ELMNA | |
| SCHEMBL13187687 | 0.78 | GRM2 (0.59) | GRM2HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL13188618 | 0.75 | MMP2 (0.47) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188540 | 0.74 | HDAC1 (0.53) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13187832 | 0.73 | HDAC6 (0.54) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13187814 | 0.73 | HDAC1 (0.61) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13188436 | 0.72 | DHODH (0.54) | GRM2HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL18895622 | 0.72 | GRM2 (0.82) | GRM2 | |
| SCHEMBL14921332 | 0.72 | GRM2 (1.00) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |