Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187832 | 0.80 | HDAC6 (0.54) | LMNAHTTMTORPIK3CAHDAC6 | |
| SCHEMBL13188764 | 0.80 | POLB (0.50) | HSD17B10LMNAPOLBHTTGPR55 | |
| SCHEMBL13188236 | 0.78 | KDM4E (0.40) | HSD17B10LMNAPOLBHTTGPR55 | |
| SCHEMBL28161448 | 0.77 | PIK3CA (0.67) | HSD17B10MTORPIK3CAPIK3CGPIK3CB | |
| SCHEMBL10327925 | 0.76 | PIK3CA (0.54) | HSD17B10LMNAPOLBHTTGPR55 | |
| SCHEMBL2369891 | 0.75 | MTOR (0.65) | MTORPIK3CAPIK3CGPIK3CBGAA | |
| SCHEMBL13188766 | 0.73 | ABL1 (0.52) | LMNAHDAC6PIK3CGGAA | |
| SCHEMBL1734333 | 0.73 | HSD17B10 (1.00) | HSD17B10LMNAPOLBHTTGPR55 | |
| SCHEMBL10327687 | 0.73 | PIK3CA (0.66) | MTORPIK3CAPIK3CGPIK3CB | |
| SCHEMBL13188805 | 0.72 | CYP1A2 (0.51) | HSD17B10LMNAHDAC6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |