Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188314 | 0.78 | HSD17B10 (0.57) | KDM4EHTTHPGDHSD17B10TSHR | |
| SCHEMBL13188766 | 0.65 | ABL1 (0.52) | GAALMNAHDAC6HDAC3MAPT | |
| SCHEMBL13187832 | 0.64 | HDAC6 (0.54) | HTTTSHRLMNAUSP2MTOR | |
| SCHEMBL3717048 | 0.61 | KDM4E (0.52) | KDM4EHTTGLAHPGDHSD17B10 | |
| SCHEMBL13187685 | 0.61 | HDAC6 (0.57) | MKNK1MKNK2HDAC6HDAC3HDAC1 | |
| SCHEMBL13188764 | 0.61 | POLB (0.50) | HTTHSD17B10GAALMNAPOLB | |
| SCHEMBL13187931 | 0.60 | HDAC6 (0.48) | MKNK1MKNK2HDAC6HDAC3DHODH | |
| SCHEMBL13188368 | 0.60 | ABL1 (0.44) | HDAC6HDAC3ABL1HDAC1HDAC2 | |
| SCHEMBL3713050 | 0.59 | TSHR (0.44) | KDM4EHTTGLAHPGDHSD17B10 | |
| SCHEMBL1734410 | 0.59 | KDM4E (0.97) | KDM4EHTTGLAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |