Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31704881 | 0.97 | ALDH1A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL3714867 | 0.97 | ALDH1A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL29771391 | 0.97 | ALDH1A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL31705350 | 0.97 | ALDH1A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL10028685 | 0.95 | ALDH1A1 (0.66) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL13044192 | 0.90 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL2345607 | 0.88 | CYP19A1 (0.74) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL9008962 | 0.88 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1ALDH1A1MKNK1 | |
| SCHEMBL10028698 | 0.86 | CYP19A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 | |
| SCHEMBL3511516 | 0.86 | CYP19A1 (0.68) | CYP11B1CYP11B2CYP19A1ALDH1A1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |