Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188516 | 0.88 | SMPD1 (0.50) | WNT3ASMPD1HDAC6DHODH | |
| SCHEMBL3716099 | 0.88 | FFAR1 (0.41) | WNT3ALMNADYRK1ADYRK1BKDM4E | |
| SCHEMBL13187710 | 0.87 | WNT3A (0.51) | WNT3ALMNADYRK1ADYRK1BKDM4E | |
| SCHEMBL13188622 | 0.85 | SMPD1 (0.52) | LMNASMPD1POLBKMT2AHDAC6 | |
| SCHEMBL13188617 | 0.84 | HDAC6 (0.50) | SMPD1HDAC6DHODH | |
| SCHEMBL13188515 | 0.84 | HDAC6 (0.45) | WNT3ASMPD1HDAC6DHODH | |
| SCHEMBL13187833 | 0.83 | ADORA3 (0.53) | SMPD1KDM4EALDH1A1HDAC6RAB9A | |
| SCHEMBL13188800 | 0.83 | HDAC1 (0.55) | LMNASMPD1ALDH1A1HSD17B10HDAC6 | |
| SCHEMBL13188875 | 0.82 | MKNK1 (0.55) | LMNASMPD1KMT2AHDAC6DHODH | |
| SCHEMBL13188334 | 0.82 | HDAC6 (0.43) | WNT3ASMPD1MEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |