Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHKA | P35790 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711313 | 0.93 | MAPK1 (0.49) | SMN1; SMN2MAPK1PARP1KMT2AKLKB1 | |
| SCHEMBL13188492 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1HRH3PARP1KMT2A | |
| SCHEMBL13187835 | 0.87 | TBK1 (0.43) | SMN1; SMN2MAPK1HRH3ACVR1HIF1A | |
| SCHEMBL13188605 | 0.86 | HDAC6 (0.58) | HRH3PARP1KLKB1JAK2ACVR1 | |
| SCHEMBL13187747 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1HRH3KMT2ACHKA | |
| SCHEMBL13188330 | 0.83 | HDAC1 (0.56) | SMN1; SMN2MAPK1HRH3KMT2ACHKA | |
| SCHEMBL3717935 | 0.82 | MAPK1 (0.50) | SMN1; SMN2MAPK1KMT2AACP1 | |
| SCHEMBL13188418 | 0.82 | JAK1 (0.53) | SMN1; SMN2MAPK1KMT2ACHKAJAK2 | |
| SCHEMBL3713032 | 0.81 | MTOR (0.40) | SMN1; SMN2MAPK1HRH3KMT2ATSHR | |
| SCHEMBL13188473 | 0.81 | PIK3CA (0.46) | SMN1; SMN2MAPK1HRH3PARP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |