Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714253 | 0.93 | HDAC1 (0.52) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13188494 | 0.87 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13188421 | 0.87 | HDAC6 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13188488 | 0.86 | SMN1; SMN2 (0.53) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13187973 | 0.84 | HDAC1 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13188892 | 0.81 | HDAC6 (0.52) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13188565 | 0.81 | HDAC6 (0.50) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3720406 | 0.81 | HDAC1 (0.52) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3711313 | 0.80 | MAPK1 (0.49) | PARP1KLKB1JAK2 | |
| SCHEMBL13188498 | 0.79 | HDAC1 (0.49) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |