Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 1/20 | 0.46 |
| ▸ | CASP5 | P51878 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715164 | 0.89 | HIF1A (0.54) | HIF1AEPAS1CASP1CASP4CASP5 | |
| SCHEMBL13188438 | 0.89 | PIM1 (0.43) | HIF1AEPAS1KITHDAC1HDAC6 | |
| SCHEMBL13188362 | 0.88 | HDAC6 (0.44) | HIF1AEPAS1HDAC1HDAC6MAPT | |
| SCHEMBL13188606 | 0.87 | CYP3A4 (0.45) | HIF1AEPAS1HDAC1HDAC6HDAC3 | |
| SCHEMBL13188807 | 0.87 | HIF1A (0.42) | HIF1AEPAS1KITHDAC1HDAC6 | |
| SCHEMBL3710083 | 0.87 | KIT (0.42) | HIF1AEPAS1KITHDAC1HDAC2 | |
| SCHEMBL13188819 | 0.87 | P4HTM (0.43) | HIF1AEPAS1KITHDAC1 | |
| SCHEMBL3713490 | 0.87 | HDAC6 (0.45) | HIF1AEPAS1HDAC1HDAC6MAPT | |
| SCHEMBL3719717 | 0.86 | MAPT (0.41) | HIF1AEPAS1HDAC1HDAC6HDAC3 | |
| SCHEMBL13187703 | 0.85 | PRKD1 (0.44) | HIF1AEPAS1HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |