Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188362 | 0.92 | HDAC6 (0.44) | PRKD1PRKD2HDAC1ALDH1A1HIF1A | |
| SCHEMBL3713490 | 0.91 | HDAC6 (0.45) | PRKD1PRKD2HDAC1ALDH1A1HIF1A | |
| SCHEMBL13187724 | 0.90 | CYP3A4 (0.44) | KITPRKD1PRKD2KDM1AHDAC1 | |
| SCHEMBL3719717 | 0.90 | MAPT (0.41) | HDAC1ALDH1A1HIF1AEPAS1 | |
| SCHEMBL13188438 | 0.89 | PIM1 (0.43) | KITHDAC1ALDH1A1HIF1AEPAS1 | |
| SCHEMBL3709548 | 0.89 | ALDH1A1 (0.42) | KITPRKD1PRKD2DYRK1ATRPV4 | |
| SCHEMBL13188771 | 0.89 | PIK3CA (0.48) | KDM1AHDAC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13187703 | 0.89 | PRKD1 (0.44) | PRKD1PRKD2HDAC1HRH4HRH3 | |
| SCHEMBL13188819 | 0.89 | P4HTM (0.43) | KITHDAC1DYRK1AHRH3HIF1A | |
| SCHEMBL13188331 | 0.89 | NPC1 (0.41) | HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |