Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713490 | 0.99 | HDAC6 (0.45) | HDAC6HDAC1HIF1AEPAS1PRKD3 | |
| SCHEMBL3710083 | 0.92 | KIT (0.42) | HDAC1HIF1AEPAS1PRKD1PRKD2 | |
| SCHEMBL13188771 | 0.92 | PIK3CA (0.48) | HDAC6HDAC1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13187703 | 0.92 | PRKD1 (0.44) | HDAC1HIF1AEPAS1PRKD3PRKD1 | |
| SCHEMBL3719717 | 0.91 | MAPT (0.41) | HDAC6HDAC1HIF1AEPAS1PIK3CA | |
| SCHEMBL3715649 | 0.89 | HIF1A (0.38) | HDAC6HDAC1HIF1AEPAS1GRM5 | |
| SCHEMBL13188438 | 0.88 | PIM1 (0.43) | HDAC6HDAC1HIF1AEPAS1ALDH1A1 | |
| SCHEMBL13188331 | 0.88 | NPC1 (0.41) | HIF1AEPAS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13188522 | 0.88 | HIF1A (0.56) | HDAC6HDAC1HIF1AEPAS1SMN1; SMN2 | |
| SCHEMBL3711841 | 0.87 | CYP19A1 (0.42) | HDAC6HDAC1HIF1AEPAS1PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |