Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10858769 | 0.77 | LMNA (0.57) | LMNACA12CA1CA2CA3 | |
| SCHEMBL323591 | 0.77 | LMNA (0.53) | LMNACA12CA1CA2CA3 | |
| SCHEMBL1759493 | 0.75 | LMNA (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL9935474 | 0.74 | LMNA (0.62) | LMNACA12CA1CA2CA3 | |
| SCHEMBL24796250 | 0.74 | LMNA (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL2411271 | 0.74 | LMNA (0.54) | LMNACA12CA1CA2CA3 | |
| SCHEMBL6989879 | 0.72 | LMNA (0.55) | LMNACA12CA1CA2CA3 | |
| SCHEMBL5315883 | 0.71 | LMNA (0.58) | LMNACA12CA1CA2CA3 | |
| SCHEMBL2372821 | 0.71 | LMNA (0.62) | LMNACA12CA1CA2CA3 | |
| SCHEMBL692195 | 0.71 | LMNA (0.58) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969739-B2 | Tricyclic chiral compounds and their use in asymmetric catalysis | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2018-05-15 | — | — | US | disclosed |
| US-20160207932-A1 | NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS | UNIV NANYANG TECH (SG) | 2016-07-21 | — | — | US | disclosed |
| US-9206090-B2 | Tricyclic chiral compounds and their use in asymmetric catalysis | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-12-08 | — | — | US | disclosed |
| US-20110269972-A1 | NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2011-11-03 | — | — | US | disclosed |
| WO-2010027334-A1 | NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-03-11 | — | — | WO | disclosed |
| US-5912352-A | CATALYTIC REDUCTION OF HYDRAZIDE TO HYDRAZINE DERIVATIVE IN PRESENCE OF COMPLEX HYDRIDE; ACYL MIGRATION; HYDROGENATION; CATALYST SELECTIVITY | NOVARTIS FINANCE CORPORATION (US) | 1999-06-15 | — | — | US | disclosed |
| WO-1997046514-A1 | PROCESS FOR THE PREPARATION OF HYDRAZINE DERIVATIVES USEFUL AS INTERMEDIATES FOR THE PREPARATION OF PEPTIDE ANALOGUES | NOVARTIS AG (CH) | 1997-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269972-A1 | NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS | SCO2, CBR3, HCCS | LMNA 4107/4885CA12 81/4885CA1 286/4885 |
| US-20160207932-A1 | NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS | COX6C, CBR3, CYCS | LMNA 2287/4885CA12 327/4885CA1 258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.