Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11892715 | 0.86 | NPC1 (0.54) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL8370362 | 0.86 | DPP4 (0.54) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL6293568 | 0.84 | POLB (0.61) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL10118388 | 0.84 | NPC1 (0.52) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL13189047 | 0.82 | DPP4 (0.49) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL14259818 | 0.82 | ALDH1A1 (0.49) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL14229666 | 0.81 | NPC1 (0.59) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL16677200 | 0.80 | MEN1 (0.56) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL13188573 | 0.80 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL27548889 | 0.79 | NPC1 (0.45) | NPC1RAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |