SCHEMBL13190098 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	1/20	0.47

▸	TAS1R3	Q7RTX0	6/20	0.43

▸	TAS1R1	Q7RTX1	6/20	0.43

▸	TAS1R2	Q8TE23	6/20	0.43

▸	SPTLC2	O15270	1/20	0.40

▸	RAB9A	P51151	2/20	0.40

▸	NPC1	O15118	1/20	0.40

▸	PYGL	P06737	2/20	0.39

▸	MAPT	P10636	1/20	0.39

▸	THRB	P10828	1/20	0.39

▸	TP53	P04637	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL883780	0.90	ALDH1A1 (0.45)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL13190008	0.90	ALDH1A1 (0.45)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL785920	0.88	ALDH1A1 (0.47)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL883801	0.88	CRBN (0.42)	ALDH1A1TAS1R3TAS1R1TAS1R2RAB9A
SCHEMBL786085	0.88	ALDH1A1 (0.47)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL883818	0.82	ALDH1A1 (0.52)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL484844	0.82	ALDH1A1 (0.49)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL784976	0.82	ALDH1A1 (0.49)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL784602	0.81	ALDH1A1 (0.50)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2
SCHEMBL784603	0.81	ALDH1A1 (0.50)	ALDH1A1TAS1R3TAS1R1TAS1R2SPTLC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2010108651-A1	SUBSTITUTED SPIRO-AMIDE COMPOUNDS	Grünenthal GmbH (DE)	2010-09-30	—	—	WO	disclosed