Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13196439 | 0.90 | POLB (0.39) | POLBEGLN1CDK8CTSDBACE1 | |
| SCHEMBL13196453 | 0.85 | POLB (0.40) | POLBEGLN1CTSDBACE1HTT | |
| SCHEMBL13196447 | 0.80 | CNR2 (0.37) | POLBEGLN1CDK8HTTELANE | |
| SCHEMBL2782930 | 0.78 | POLB (0.43) | POLBHTTKDM4EANPEPL3MBTL1 | |
| SCHEMBL2781518 | 0.77 | CNR2 (0.52) | POLBHTTANPEPL3MBTL1TSHR | |
| SCHEMBL13196558 | 0.76 | NAMPT (0.39) | POLBEGLN1CDK8HTTELANE | |
| SCHEMBL2781233 | 0.72 | GAA (0.53) | POLBCTSDBACE1KDM4CGCK | |
| SCHEMBL2783319 | 0.70 | POLB (0.40) | POLBKDM4EANPEPL3MBTL1TSHR | |
| SCHEMBL13196604 | 0.70 | CNR2 (0.40) | POLBEGLN1KDM4EANPEPL3MBTL1 | |
| SCHEMBL2779887 | 0.69 | CNR2 (0.52) | POLBHTTANPEPL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090680-A1 | SUBSTITUTED OXINDOLE CB2 AGONISTS | WYETH LLC (US) | 2010-08-12 | — | — | WO | disclosed |