Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 9/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842588 | 0.92 | CTSK (0.59) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL7696221 | 0.92 | CTSK (0.59) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL14338698 | 0.92 | CTSK (0.59) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL7729227 | 0.87 | CTSK (0.55) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL7375068 | 0.87 | CTSK (0.55) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL21715604 | 0.86 | CTSK (0.56) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL28448310 | 0.86 | ATM (0.64) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL1022839 | 0.86 | CTSS (0.49) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL4895955 | 0.85 | CTSS (0.48) | ATMCTSKCTSSSYKCTSL | |
| SCHEMBL27725038 | 0.84 | PPARA (0.56) | ATMCTSKCTSSSYKMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091104-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EXELIXIS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |
| US-7560477-B2 | Compounds active in sphingosine 1-phosphate signaling | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-7560477-B2 | Compounds active in sphingosine 1-phosphate signaling | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-20070219163-A1 | Compounds Active in Sphingosine 1-Phosphate Signaling | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2007-09-20 | — | — | US | disclosed |
| US-20070219163-A1 | Compounds Active in Sphingosine 1-Phosphate Signaling | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219163-A1 | Compounds Active in Sphingosine 1-Phosphate Signaling | S1PR3, S1PR1, S1PR5 | ATM 2552/4885CTSK 3556/4885CTSS 2282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.