Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 12/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267641 | 0.96 | SSTR3 (0.39) | TACR1SSTR3SSTR1ALDH1A1LMNA | |
| SCHEMBL8267733 | 0.93 | MCHR1 (0.38) | TACR1SSTR3POLBNPC1HSD17B10 | |
| SCHEMBL13199216 | 0.89 | TACR1 (0.42) | TACR1ALDH1A1LMNAPOLBMEN1 | |
| SCHEMBL11923227 | 0.89 | HSD17B10 (0.43) | TACR1MEN1KMT2AHSD17B10 | |
| SCHEMBL11923264 | 0.87 | MAPT (0.35) | TACR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11923256 | 0.87 | JAK1 (0.38) | TACR1HSD17B10 | |
| SCHEMBL11923272 | 0.85 | WDR5 (0.39) | TACR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11923231 | 0.84 | TACR1 (0.42) | TACR1ALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL8266441 | 0.79 | HSD17B10 (0.45) | TACR1MEN1KMT2AHSD17B10 | |
| SCHEMBL8267651 | 0.79 | CHRM2 (0.37) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767680-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767680-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-03 | — | — | US | disclosed |