Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923231 | 0.95 | TACR1 (0.42) | TACR1ALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL13199159 | 0.89 | TACR1 (0.37) | TACR1ALDH1A1LMNANPC1HTT | |
| SCHEMBL11923244 | 0.87 | HSD17B10 (0.48) | TACR1POLBHSD17B10KMT2AMEN1 | |
| SCHEMBL8267812 | 0.86 | TACR1 (0.42) | TACR1POLBHSD17B10MAPTCNR2 | |
| SCHEMBL8266182 | 0.86 | GAA (0.42) | TACR1ALDH1A1POLBHSD17B10KMT2A | |
| SCHEMBL8267739 | 0.86 | TACR1 (0.38) | TACR1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL8267641 | 0.84 | SSTR3 (0.39) | TACR1ALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL8266167 | 0.84 | TACR1 (0.44) | TACR1POLBHSD17B10KMT2AMEN1 | |
| SCHEMBL2961003 | 0.84 | WDR5 (0.43) | TACR1ALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL2952189 | 0.82 | THRB (0.48) | TACR1ALDH1A1LMNAHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767680-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767680-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-03 | — | — | US | disclosed |