Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12590875 | 0.78 | ABCB1 (0.49) | ABCB1CA1CA2CA7POLB | |
| SCHEMBL10235503 | 0.78 | ABCB1 (0.49) | ABCB1CA1CA2CA7POLB | |
| SCHEMBL4186965 | 0.78 | HCAR3 (0.60) | POLBKMT2AL3MBTL1NPSR1TP53 | |
| SCHEMBL19763766 | 0.76 | KMT2A (0.49) | POLBKMT2AL3MBTL1NPSR1TP53 | |
| SCHEMBL20515889 | 0.76 | KMT2A (0.49) | POLBKMT2AL3MBTL1NPSR1TP53 | |
| SCHEMBL19763764 | 0.76 | KMT2A (0.49) | POLBKMT2AL3MBTL1NPSR1TP53 | |
| SCHEMBL28934823 | 0.75 | POLB (0.48) | POLBKMT2AL3MBTL1NPSR1TP53 | |
| SCHEMBL26027315 | 0.74 | TRPA1 (0.41) | CA1CA2CA7KMT2A | |
| SCHEMBL1232913 | 0.74 | POLB (0.41) | ABCB1POLBKMT2AL3MBTL1NPSR1 | |
| SCHEMBL1058980 | 0.74 | ABCB1 (0.73) | ABCB1POLBKMT2ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767687-B2 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors | BIOGEN IDEC MA INC. (US) | 2010-08-03 | — | — | US | disclosed |