Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199934 | 0.88 | KDM4E (0.71) | RAF1EGFRKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2944830 | 0.81 | RAF1 (0.66) | RAF1SMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL13234650 | 0.79 | RAF1 (0.60) | RAF1EGFRKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3550019 | 0.79 | RAF1 (0.71) | RAF1 | |
| SCHEMBL13200602 | 0.79 | FLT3 (0.77) | RAF1EGFRMEN1NPC1MAPT | |
| SCHEMBL13199988 | 0.78 | RET (0.62) | RAF1EGFRKDM4EALDH1A1MEN1 | |
| SCHEMBL3184301 | 0.78 | EGFR (0.54) | RAF1EGFRKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL13234432 | 0.78 | RAF1 (0.93) | RAF1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4104287 | 0.76 | EGFR (0.70) | RAF1TSHREGFRSMN1; SMN2MEN1 | |
| SCHEMBL13234777 | 0.76 | FLT3 (0.80) | RAF1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |