Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 6/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200555 | 0.90 | FLT3 (0.73) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234777 | 0.89 | FLT3 (0.80) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234705 | 0.87 | FLT3 (1.00) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200418 | 0.85 | FLT3 (0.73) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200037 | 0.85 | FLT3 (0.73) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200522 | 0.83 | FLT3 (0.69) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234708 | 0.83 | FLT3 (0.88) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200580 | 0.83 | FLT3 (0.72) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13234414 | 0.82 | FLT3 (0.79) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200435 | 0.81 | FLT3 (0.66) | FLT3MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |